DNA Laser Printing

 

Abundance co-author Steven Kotler recently wrote in the Forbes Blog about a significant upshift in DNA synthesis technology.  It’s called DNA Laser Printing.  Created by a Bay Area startup called Cambrian Genomics, the technique solves a thorny problem with chemistry-based DNA synthesis: make a long enough oligonucleotide and it will contain errors.  This happens because the chemistries are on average 99% efficient.  Cambrian solves this problem by leveraging the incredible accuracy of modern DNA sequencers.  DNA is attached to small beads, the beads attached to a slide, and then sequencing by synthesis is performed.  The result is not just the exact sequence of the DNA on the bead, but the exact location of the bead on the slide.  The slide is removed from the sequencer and a laser beam is used to specifically remove just the beads of interest.  The result?  A 1000x or more reduction in the cost of getting accurate DNA, and no limitations of the size of DNA chain. Cambrian is still developing the technology and people are watching.  The Carlson Curve marches on…

See Steven’s full post here.